Article
Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2018
Shen Hong, Christopher Lisa, Lai Yurong, Gong Jiachang, Kandoussi Hamza, Garonzik Samira, Perera Vidya, Garimella Tushar, Humphreys W Griffith
Abstract excerpt
In a recent study, limited to South Asian Indian subjects (n = 12), coproporphyrin (CP) I and CPIII demonstrated properties appropriate for an organic anion-transporting polypeptide (OATP) 1B endogenous probe. The current studies were conducted in healthy volunteers of mixed ethnicities, including black, white, and Hispanic subjects, to better understand the utility of these biomarkers in broader populations....
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