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Article

Biomarker-Based Prediction of OATP1B1 Activity in Clinical Routine-Investigating Coproporphyrins as Markers for Drug-Drug-Gene Interactions.

Clinical pharmacology and therapeutics - 1 Aug 2026

Potzel Leila, Zumtaugwald Anina, Bollinger Anna, Jeiziner Chiara, Hersberger Kurt E, Wiss Florine, Lampert Markus L, Allemann Samuel S, Meyer Zu Schwabedissen Henriette E, Stäuble Céline K

Abstract excerpt

Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug-drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre- and post-OATP1B1-inhibitor sampling, its applicability in samples obtained in clinical routine from multimorbid,...

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Identifiers

PMID: 42145189
DOI: 10.1002/cpt.70335
PMCID: PMC13339200

Genes

CP
SLCO1B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Biomarker-Based Prediction of OATP1B1 Activity in Clinical Routine-Investigating Coproporphyrins as Markers for Drug-Drug-Gene Interactions.PMID 42145189Read ↗

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