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Article

Substantially Increased Plasma Coproporphyrin-I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population.

Clinical and translational science - 1 Jan 2021

Suzuki Yosuke, Sasamoto Yuri, Koyama Teruhide, Yoshijima Chisato, Nakatochi Masahiro, Kubo Michiaki, Momozawa Yukihide, Uehara Ritei, Ohno Keiko

Abstract excerpt

Coproporphyrin-I (CP-I) in plasma is a sensitive and specific endogenous probe for phenotyping organic anion transporting polypeptides 1B (OATP1B, encoded by SLCO1B). A few small-scale studies suggested that plasma CP-I concentration is affected by OATP1B1 polymorphism, but detailed studies are lacking. In this large-scale study, we measured plasma CP-I concentrations in 391 subjects from the Japanese general...

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Identifiers

PMID: 32961019
DOI: 10.1111/cts.12889
PMCID: PMC7877856

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