Article
Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel.
Drug metabolism and disposition: the biological fate of chemicals - 1 May 2020
Mori Daiki, Ishida Hiroo, Mizuno Tadahaya, Kusumoto Sojiro, Kondo Yusuke, Izumi Saki, Nakata Genki, Nozaki Yoshitane, Maeda Kazuya, Sasaki Yasutsuna, Fujita Ken-Ichi, Kusuhara Hiroyuki
Abstract excerpt
Paclitaxel has been considered to cause OATP1B-mediated drug-drug interactions at therapeutic doses; however, its clinical relevance has not been demonstrated. This study aimed to elucidate in vivo inhibition potency of paclitaxel against OATP1B1 and OATP1B3 using endogenous OATP1B biomarkers. Paclitaxel is an inhibitor of OATP1B1 and OATP1B3, with Ki of 0.579 ± 0.107 and 5.29 ± 3.87 μM, respectively....
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