Article

OATP1B1 plays an important role in the transport and treatment efficacy of sorafenib in hepatocellular carcinoma

2022-03-30

Abstract excerpt

ABSTRACT Background: Sorafenib is an anticancer drug used in the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It is a substrate for the human OATP1B1. This study aimed to assess the role of OATP1B1 in transportation and uptake of sorafenib in hepatocellular carcinoma and how OATP1B1 affects the pharmacodynamics of sorafenib in vitro and in vivo. <h4>Methods:</h4> Sorafenib...

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Literature Corpus work: e008c42e-deec-5514-80d5-5e9f87c8e02e
DOI: 10.22541/au.164864919.94371010/v1

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