Article
Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
British journal of cancer - 27 Apr 2010
Xu C-F, Reck B H, Xue Z, Huang L, Baker K L, Chen M, Chen E P, Ellens H E, Mooser V E, Cardon L R, Spraggs C F, Pandite L
Abstract excerpt
BACKGROUND: Pazopanib has shown clinical activity against multiple tumour types and is generally well tolerated. However, isolated elevations in transaminases and bilirubin have been observed. This study examined polymorphisms in molecules involved in pharmacokinetic and pharmacodynamic pathways of pazopanib and their association with hepatic dysfunction. METHODS: Twenty-eight polymorphisms in 11 genes were...
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