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Article

PBPK Model of Coproporphyrin I: Evaluation of the Impact of SLCO1B1 Genotype, Ethnicity, and Sex on its Inter-Individual Variability.

CPT: pharmacometrics & systems pharmacology - 1 Feb 2021

Takita Hiroyuki, Barnett Shelby, Zhang Yueping, Ménochet Karelle, Shen Hong, Ogungbenro Kayode, Galetin Aleksandra

Abstract excerpt

Coproporphyrin I (CPI) is an endogenous biomarker of OATP1B activity and associated drug-drug interactions. In this study, a minimal physiologically-based pharmacokinetic model was developed to investigate the impact of OATP1B1 genotype (c.521T>C), ethnicity, and sex on CPI pharmacokinetics and interindividual variability in its baseline. The model implemented mechanistic descriptions of CPI hepatic transport...

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Biological Transport
Drug Development
Drug Interactions
Healthy Volunteers
Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver-Specific Organic Anion Transporter 1

Observer Variation

Sex Characteristics

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PMID: 33289952
DOI: 10.1002/psp4.12582
PMCID: PMC7894406

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