Article

Redox-mediated regulation of a labile, evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

2019-12-27

Abstract excerpt

<h4>Summary</h4> An evolutionarily conserved low complexity (LC) domain is found within a 152 residue segment localized to the carboxyl-terminal region of the TDP43 RNA-binding protein. This TDP43 LC domain contains ten conserved methionine residues. Self-association of this domain leads to the formation of liquid-like droplets composed of labile, cross-β polymers. Exposure of polymers to low concentrations of H...

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Literature Corpus work: 8381dbe3-6c20-59ae-91fe-29ddca7c3184
DOI: 10.1101/2019.12.24.885962

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