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Article

Molecular mechanism of oxidation‐induced TDP‐43 RRM1 aggregation and loss of function

4 Feb 2013

Abstract excerpt

Cysteine oxidation of the two RNA recognition motifs (RRM1 and RRM2) of TDP-43, a multi-domain protein involved in neurodegenerative diseases, results in loss of function and accumulation of insoluble aggregates under both in vitro and in vivo conditions. However, the molecular mechanisms linking cysteine oxidation to protein aggregation and functional aberration remain unknown. We report that oxidation of...

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PMID: 23384725
DOI: 10.1016/j.febslet.2013.01.038

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