Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

Abstract excerpt

Significance The TDP43 RNA binding protein is frequently aggregated in the brain tissue of patients suffering from neurodegenerative diseases. Human genetic studies of patients suffering from ALS have identified scores of missense mutations clustered within a localized region of the TDP43 protein. This region is of low sequence complexity and has been thought to exist in a state of structural disorder under...

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