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Article

Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

27 Sept 2019

Abstract excerpt

The defining pathological hallmarks of Alzheimer's disease (AD) are proteinopathies marked by the amyloid-β (Aβ) peptide and hyperphosphorylated tau. In addition, Hirano bodies and cofilin-actin rods are extensively found in AD brains, both of which are associated with the actin cytoskeleton. The actin-binding protein cofilin known for its actin filament severing, depolymerizing, nucleating, and bundling...

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PMID: 31594228
DOI: 10.3233/jad-190585

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