Article

SOD1 Catalyses Thiol Oxidation to Thiosulfinates

2026-06-05

Abstract excerpt

Cu/Zn superoxide dismutase (SOD1) is canonically regarded as a superoxide scavenging antioxidant yet is paradoxically associated with multiple diseases. Here, we show that SOD1 catalyzes thiol oxidation to thiosulfinates (RS(O)SR), revealing a previously unrecognized copper mediated oxidant forming reaction in biology. Steady state kinetics demonstrate robust, O 2 dependent thiol consumption, and ATR FTIR spectra...

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Literature Corpus work: 836aec4b-ddd1-5c18-8043-a0b66fa5d023
DOI: 10.64898/2026.06.03.729904

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