Article
The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase.
The Journal of biological chemistry - 29 Sept 2006
Carroll Mark C, Outten Caryn E, Proescher Jody B, Rosenfeld Leah, Watson Walter H, Whitson Lisa J, Hart P John, Jensen Laran T, Cizewski Culotta Valeria
Abstract excerpt
Mutations in Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral sclerosis (ALS) through mechanisms proposed to involve SOD1 misfolding, but the intracellular factors that modulate folding and stability of SOD1 are largely unknown. By using yeast and mammalian expression systems, we demonstrate here that SOD1 stability is governed by post-translational modification factors that target the SOD1...
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