Article

A novel SOD1-dependent mechanism for the iron-induced production of toxic SOD1 and oxidative stress that initiates ALS

2015-05-01

Abstract excerpt

Free iron is highly toxic and the blood-derived iron initiates early motor-neuron degeneration upon breakdown of blood-spinal cord barrier. Iron is currently known to trigger oxidative stress by Fenton chemistry but no report implies that iron manifests its toxicity through CuZn-superoxide dismutase (SOD1), the central antioxidant enzyme in all human tissues that carries >180 ALS-causing mutations. Here, by NMR we...

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Literature Corpus work: e70f86e3-0b82-5feb-a5c5-a25e599f708a
DOI: 10.1101/018846

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