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Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast.

Free radical biology & medicine - 1 Jan 2025

Zimmermann Jannik, Lang Lukas, Calabrese Gaetano, Laporte Hugo, Amponsah Prince S, Michalk Christoph, Sukmann Tobias, Oestreicher Julian, Tursch Anja, Peker Esra, Owusu Theresa N E, Weith Matthias, Roma Leticia Prates, Deponte Marcel, Riemer Jan, Morgan Bruce

Abstract excerpt

Hydrogen peroxide (H2O2) is an important biological molecule, functioning both as a second messenger in cell signaling and, especially at higher concentrations, as a cause of cell damage. Cells harbor multiple enzymes that have peroxide reducing activity in vitro. However, the contribution of each of these enzymes towards peroxide scavenging in vivo is less clear. Therefore, to directly investigate in vivo...

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PMID: 39515595
DOI: 10.1016/j.freeradbiomed.2024.11.004

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