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Article

Oxidative misfolding of Cu/Zn-superoxide dismutase triggered by non-canonical intramolecular disulfide formation.

Free radical biology & medicine - 1 Feb 2020

Anzai Itsuki, Tokuda Eiichi, Handa Sumika, Misawa Hidemi, Akiyama Shuji, Furukawa Yoshiaki

Abstract excerpt

Misfolded Cu/Zn-superoxide dismutase (SOD1) is a pathological species in a subset of amyotrophic lateral sclerosis (ALS). Oxidative stress is known to increase in affected spinal cords of ALS and is thus considered to cause damages on SOD1 leading to the misfolding and aggregation. Despite this, it still remains elusive what triggers misfolding of SOD1 under oxidizing environment. Here, we show that a thiol group...

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PMID: 31863908
DOI: 10.1016/j.freeradbiomed.2019.12.017

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