Article
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis.
The Journal of biological chemistry - 6 Dec 2002
Rakhit Rishi, Cunningham Patricia, Furtos-Matei Alexandra, Dahan Sophie, Qi Xiao-Fei, Crow John P, Cashman Neil R, Kondejewski Leslie H, Chakrabartty Avijit
Abstract excerpt
The presence of intracellular aggregates that contain Cu/Zn superoxide dismutase (SOD1) in spinal cord motor neurons is a pathological hallmark of amyotrophic lateral sclerosis (ALS). Although SOD1 is abundant in all cells, its half-life in motor neurons far exceeds that in any other cell type. On the basis of the premise that the long half-life of the protein increases the potential for oxidative damage, we...
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