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Article

Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site.

The Journal of biological chemistry - 21 Jul 2017

Fetherolf Morgan M, Boyd Stefanie D, Taylor Alexander B, Kim Hee Jong, Wohlschlegel James A, Blackburn Ninian J, Hart P John, Winge Dennis R, Winkler Duane D

Abstract excerpt

Metallochaperones are a diverse family of trafficking molecules that provide metal ions to protein targets for use as cofactors. The copper chaperone for superoxide dismutase (Ccs1) activates immature copper-zinc superoxide dismutase (Sod1) by delivering copper and facilitating the oxidation of the Sod1 intramolecular disulfide bond. Here, we present structural, spectroscopic, and cell-based data supporting a...

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Identifiers

PMID: 28533431
DOI: 10.1074/jbc.M117.775981
PMCID: PMC5519355

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