Article
Shelterin components mediate genome reorganization in response to replication stress.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 2017
Mizuguchi Takeshi, Taneja Nitika, Matsuda Emiko, Belton Jon-Matthew, FitzGerald Peter, Dekker Job, Grewal Shiv I S
Abstract excerpt
The dynamic nature of genome organization impacts critical nuclear functions including the regulation of gene expression, replication, and DNA damage repair. Despite significant progress, the mechanisms responsible for reorganization of the genome in response to cellular stress, such as aberrant DNA replication, are poorly understood. Here, we show that fission yeast cells carrying a mutation in the DNA-binding...
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