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Article

Application of the parametric bootstrap for gene-set analysis of gene-environment interactions.

European journal of human genetics : EJHG - 1 Nov 2018

Coombes Brandon J, Biernacka Joanna M

Abstract excerpt

Testing for gene-environment (GE) interactions in a gene-set defined by a biological pathway can help us understand the interplay between genes and environments and provide insight into disease etiology. A self-contained gene-set analysis can be performed by combining gene-level p-values using approaches such as the Gamma Method. In a gene-set analysis of genetic main effects, permutation approaches are commonly...

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Identifiers

PMID: 30089830
DOI: 10.1038/s41431-018-0236-x
PMCID: PMC6189148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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