Article

Trajectory inference of epithelial-centered neighborhood profiles reconstructs a pseudo-temporal continuum in idiopathic pulmonary fibrosis

2026-06-18

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is characterized by complex lung architecture and spatially heterogeneous remodeling, which have hindered integrated analysis of cell-intrinsic activity and intercellular communication during disease progression. Here we profiled six IPF lung specimens comprising more than 630,000 cells using the Xenium 5k panel and developed an epithelial-centered neighborhoo...

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Literature Corpus work: 83582f3f-b319-58e1-924b-6b923563bf3b
DOI: 10.64898/2026.06.15.732243

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