Article
GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.
JCI insight - 7 May 2020
Kanno Ayumi, Asahara Shun-Ichiro, Furubayashi Ayuko, Masuda Katsuhisa, Yoshitomi Risa, Suzuki Emi, Takai Tomoko, Kimura-Koyanagi Maki, Matsuda Tomokazu, Bartolome Alberto, Hirota Yushi, Yokoi Norihide, Inaba Yuka, Inoue Hiroshi, Matsumoto Michihiro, Inoue Kenichi, Abe Takaya, Wei Fan-Yan, Tomizawa Kazuhito, Ogawa Wataru, Seino Susumu, Kasuga Masato, Kido Yoshiaki
Abstract excerpt
EIF2AK4, which encodes the amino acid deficiency-sensing protein GCN2, has been implicated as a susceptibility gene for type 2 diabetes in the Japanese population. However, the mechanism by which GCN2 affects glucose homeostasis is unclear. Here, we show that insulin secretion is reduced in individuals harboring the risk allele of EIF2AK4 and that maintenance of GCN2-deficient mice on a high-fat diet results in a...
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