Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes.

doi:10.1016/j.ebiom.2018.03.026

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Article

Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes.

EBioMedicine - 1 Apr 2018

Jainandunsing Sjaam, Koole H Rita, van Miert Joram N I, Rietveld Trinet, Wattimena J L Darcos, Sijbrands Eric J G, de Rooij Felix W M

Abstract excerpt

Transcription factor 7-like 2 (TCF7L2) is the main susceptibility gene for type 2 diabetes, primarily through impairing the insulin secretion by pancreatic β cells. However, the exact in vivo mechanisms remain poorly understood. We performed a family study and determined if the T risk allele of the rs7903146 in the TCF7L2 gene increases the risk of type 2 diabetes based on real-time stable isotope measurements of...

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Identifiers

PMID: 29631902
DOI: 10.1016/j.ebiom.2018.03.026
PMCID: PMC5952407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes.PMID 29631902Read ↗

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