Article

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

2024-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Selective and controlled expansion of endogenous β-cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β-cell proliferation to avoid excessive β-cell expansion and an increased risk of hypoglycemia. Here, we identified a regulator of β-cell proliferation whose inactivation results in controlled β-cell expansion: the protein deace...

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Literature Corpus work: 2da71e00-caf2-51ab-8c13-a5581e9f81db
DOI: 10.1101/2024.02.24.581864

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