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Article

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.

Journal of molecular and cellular cardiology - 1 May 2016

McNamara James W, Li Amy, Smith Nicola J, Lal Sean, Graham Robert M, Kooiker Kristina Bezold, van Dijk Sabine J, Remedios Cristobal G Dos, Harris Samantha P, Cooke Roger

Abstract excerpt

Cardiac myosin binding protein-C (cMyBP-C) is a structural and regulatory component of cardiac thick filaments. It is observed in electron micrographs as seven to nine transverse stripes in the central portion of each half of the A band. Its C-terminus binds tightly to the myosin rod and contributes to thick filament structure, while the N-terminus can bind both myosin S2 and actin, influencing their structure...

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Share to Cardiac Myosins
Share to Cardiomyopathy, Hypertrophic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mice, Knockout

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Source

Open in PubMed Open full text

Identifiers

PMID: 27021517
DOI: 10.1016/j.yjmcc.2016.03.009
PMCID: PMC4861668

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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