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Article

SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy

6 Dec 2010

Abstract excerpt

Loss-of-function mutations in the genes encoding dystrophin and the associated membrane proteins, the sarcoglycans, produce muscular dystrophy and cardiomyopathy. The dystrophin complex provides stability to the plasma membrane of striated muscle during muscle contraction. Increased SMAD signaling due to activation of the transforming growth factor-β (TGFβ) pathway has been described in muscular dystrophy;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21138941
DOI: 10.1093/hmg/ddq528

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