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Article

Ablation of the murine alpha myosin heavy chain gene leads to dosage effects and functional deficits in the heart.

The Journal of clinical investigation - 15 Oct 1996

Jones W K, Grupp I L, Doetschman T, Grupp G, Osinska H, Hewett T E, Boivin G, Gulick J, Ng W A, Robbins J

Abstract excerpt

The alpha-myosin heavy chain (alpha-MyHC) is the major contractile protein expressed in the myocardium of adult mice. We have produced mice carrying a null mutation of alpha-MyHC by homologous recombination in murine ES cells. Homozygous null animals die between 11 and 12 d in utero of gross heart defects, while alpha-MyHC+/- heterozygotes survive and appear externally normal. The presence of a single functional...

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Identifiers

PMID: 8878443
DOI: 10.1172/JCI118992
PMCID: PMC507631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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