Article

A “non-muscle” α-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodeling

2024-11-28

Abstract excerpt

<h4>ABSTRACT</h4> Cardiac sarcomeres generate the fundamental forces behind each heartbeat and are thought to contain only muscle-specific cytoskeletal proteins. We show that a widely expressed actin cross-linking protein, α-actinin 4 (ACTN4), is a sarcomere component of the human and zebrafish heart in vivo and in human iPSC-derived cardiac myocytes (CMs) in vitro . A confluence of biochemical experiments, imm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3405f41f-989c-54ff-ab3e-0ab0a953cc59
DOI: 10.1101/2024.11.26.625523

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A “non-muscle” α-actinin is an intrinsic component of the cardiac Z-disc and regulates sarcomere turnover, contractility, and heart remodelingDOI 10.1101/2024.11.26.625523Read

Identifying cardiac actinin interactomes reveals sarcomere crosstalk with RNA-binding proteinsSemantic proximity Read

Mono- and bi-allelic protein truncating variants in alpha-actinin 2 cause cardiomyopathy through distinct mechanismsSemantic proximity Read

Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractilitySemantic proximity Read

KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy <i>in vivo</i>Semantic proximity Read

Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.Semantic proximity Read

α‐Actinin‐2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α‐actinin‐3 revealing functional differences between sarcomeric isoformsSemantic proximity Read

A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heartSemantic proximity Read

The actinin family of actin cross-linking proteins – a genetic perspectiveSemantic proximity Read

The role of the M-band myomesin proteins in muscle integrity and cardiac diseaseSemantic proximity Read

Dosage-sensitive <i>RBFOX2</i> autoregulation promotes cardiomyocyte differentiation by maturing the transcriptomeSemantic proximity Read

Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.Semantic proximity Read

Muscle LIM Protein is a Non-Canonical RNA-Binding Protein that Engages in RNA-Dependent Cytoskeletal AssemblySemantic proximity Read