Structurally Oriented Classification of FOXA1 Alterations Identifies Prostate Cancers with Opposing Clinical Outcomes and Distinct Molecular and Immunologic Subtypes.

doi:10.1158/1078-0432.CCR-24-3471

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Article

Structurally Oriented Classification of FOXA1 Alterations Identifies Prostate Cancers with Opposing Clinical Outcomes and Distinct Molecular and Immunologic Subtypes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 3 Mar 2025

Hwang Justin, Likasitwatanakul Pornlada, Deshmukh Sachin Kumar, Wu Sharon, Kwon Jason J, Toye Eamon, Moline David, Evans Mark G, Elliott Andrew, Passow Rachel, Luo Christine, John Emily, Gandhi Nishant, McKay Rana R, Heath Elisabeth I, Nabhan Chadi, Reizine Natalie, Orme Jacob J, Domingo Domenech Josep M, Sartor Oliver, Baca Sylvan C, Dehm Scott M, Antonarakis Emmanuel S

Abstract excerpt

PURPOSE: Around 10% to 15% of prostate cancers harbor recurrent aberrations in the Forkhead Box A1 gene, FOXA1, whereby the alteration type and the effect on the forkhead (FKH) domain affect protein function. We developed a FOXA1 classification system to inform clinical management. EXPERIMENTAL DESIGN: A total of 5,014 prostate cancer samples were examined using whole-exome and -transcriptome sequencing from the...

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PMID: 39745364
DOI: 10.1158/1078-0432.CCR-24-3471
PMCID: PMC11873805

Genes

FOXA1

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