Article

Dynein dysfunction prevents maintenance of high concentrations of slow axonal transport cargos at the axon terminal: a computational study

2022-06-19

Abstract excerpt

Here we report computational studies of bidirectional transport in an axon, specifically focusing on predictions when the retrograde motor becomes dysfunctional. We are motivated by reports that mutations in dynein-encoding genes can cause diseases associated with peripheral motor and sensory neurons, such as type 2O Charcot-Marie-Tooth disease. We use two different models to simulate bidirectional transport in an...

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Identifiers and source

Literature Corpus work: 82c45310-bcc6-574c-9761-68469fff69b0
DOI: 10.1101/2022.06.19.496644

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