Article
Releasing the brake: restoring fast axonal transport in neurodegenerative disorders.
Trends in cell biology - 1 Dec 2013
Hinckelmann Maria-Victoria, Zala Diana, Saudou Frédéric
Abstract excerpt
Emerging evidence suggests that the dysregulation of fast axonal transport (FAT) plays a crucial role in several neurodegenerative disorders. Some of these diseases are caused by mutations affecting the molecular motors or adaptors that mediate FAT, and transport defects in organelles such as mitochondria and vesicles are observed in most, if not all neurodegenerative disorders. The relationship between...
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