Article

The sets of kinesins and dynein transporting endocytic cargoes determine the effect of tau on their motility

2022-06-10

Abstract excerpt

<h4>Summary</h4> The misregulation of tau, a neuronal microtubule-associated protein, is linked to defective axonal transport and neurodegenerative disease. We reconstituted the motility of isolated phagosomes along microtubules to ask how the sets of motors transporting a cargo determine its motility and response to tau. Using quantitative photobleaching, we find that early phagosomes (EPs) and late phagosomes (...

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Literature Corpus work: 583c67d0-c9f0-5130-8201-69abcea28369
DOI: 10.1101/2022.06.10.495679

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