Article
Methodological Approaches for Assessing Metabolomic Changes in Glioblastomas.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Nguyen Trang T T, Shang Enyuan, Westhoff Mike-Andrew, Karpel-Massler Georg, Siegelin Markus D
Abstract excerpt
Glioblastoma (GBM), a highly malignant primary brain tumor, inevitably leads to death. In the last decade, a variety of novel molecular characteristics of GBMs were unraveled. The identification of the mutation in the IDH1 and less commonly IDH2 gene was surprising and ever since has nurtured research in the field of GBM metabolism. While initially thought that mutated IDH1 were to act as a loss of function...
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