Article

Incorporation of Heterogeneity in a Case-Control Study Through a Mixture Model

2020-09-10

Abstract excerpt

Most common human diseases and complex traits are etiologically heterogeneous. Genome-wide Association Studies (GWAS) aim to discover common genetic variants that are associated with complex traits, typically without considering heterogeneity. Heterogeneity, as well as im-precise phenotyping, significantly reduces the power to find genetic variants associated with human diseases and complex traits. Disease subtypi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82bd88b0-57f1-5d08-95a8-09380d7835d2
DOI: 10.1101/2020.09.09.290437

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Incorporation of Heterogeneity in a Case-Control Study Through a Mixture ModelDOI 10.1101/2020.09.09.290437Read

Binomial mixture model-based association tests under genetic heterogeneity.Semantic proximity Read

Binomial Mixture Model Based Association Testing to Account for Genetic Heterogeneity for GWAS.Semantic proximity Read

Bayesian mixture model for clustering rare-variant effects in human genetic studiesSemantic proximity Read

Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model.Semantic proximity Read

Mixture model-based association analysis with case-control data in genome wide association studies.Semantic proximity Read

Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.Semantic proximity Read

Association mapping, using a mixture model for complex traits.Semantic proximity Read

Linkage analysis of quantitative trait loci in the presence of heterogeneity.Semantic proximity Read

A simple Bayesian mixture model with a hybrid procedure for genome-wide association studies.Semantic proximity Read

Characterizing substructure via mixture modeling in large-scale genetic summary statistics.Semantic proximity Read

Meta-analysis of genetic association studies under heterogeneity.Semantic proximity Read

Dissecting the genetic overlap between three complex phenotypes with trivariate MiXeRSemantic proximity Read