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Article

Binomial Mixture Model Based Association Testing to Account for Genetic Heterogeneity for GWAS.

Genetic epidemiology - 1 Apr 2016

Xu Zhiyuan, Pan Wei

Abstract excerpt

Genome-wide association studies (GWAS) have confirmed the ubiquitous existence of genetic heterogeneity for common disease: multiple common genetic variants have been identified to be associated, while many more are yet expected to be uncovered. However, the single SNP (single-nucleotide polymorphism) based trend test (or its variants) that has been dominantly used in GWAS is based on contrasting the allele...

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PMID: 26916514
DOI: 10.1002/gepi.21954
PMCID: PMC4814320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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