Article
Meta-analysis of genetic association studies under heterogeneity.
European journal of human genetics : EJHG - 1 Nov 2012
Neupane Binod, Loeb Mark, Anand Sonia S, Beyene Joseph
Abstract excerpt
In multi-cohort genetic association studies or meta-analysis, associations of genetic variants with complex traits across cohorts may be heterogeneous because of genuine genetic diversity or differential biases or errors. To detect the associations of genes with heterogeneous associations across cohorts, new global fixed-effect (FE) and random-effects (RE) meta-analytic methods have been recently proposed. These...
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