Article

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death

2020-01-27

Abstract excerpt

SHARPIN, together with RNF31/HOIP and RBCK1/HOIL1, form the linear ubiquitin chain assembly complex (LUBAC) E3 ligase that catalyzes M1-linked poly-ubiquitination. Mutations in RNF31/HOIP and RBCK/HOIL1 in humans and Sharpin in mice lead to auto-inflammation and immunodeficiency but the mechanism underlying the immune dysregulation remains unclear. We now show that the phenotype of the Sharpin -/- mice is dep...

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Identifiers and source

Literature Corpus work: 82bb583e-4003-50ef-9a5c-33d954e1d839
DOI: 10.1101/2020.01.27.919076

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