Article

A Novel HOIP Frameshift Variant Alleviates NF-kappaB Signaling and Sensitizes Cells to TNF-induced Death

2023-10-19

Abstract excerpt

<title>Abstract</title> <p>The linear ubiquitin chain assembly complex (LUBAC) is the sole known complex that can assemble linear ubiquitin chains. It is composed of three distinct subunits: HOIP, SHARPIN, and HOIL-1L, and has a wide range of tissue expression patterns. HOIP, the key component of LUBAC, possesses the capability to form linear ubiquitin linkages. In this study, we report a novel homozygous deletio...

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Literature Corpus work: 7ba70049-177f-5831-b916-cbe9721736c0
DOI: 10.21203/rs.3.rs-3404349/v1

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