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Article

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

eLife - 2 Dec 2014

Kumari Snehlata, Redouane Younes, Lopez-Mosqueda Jaime, Shiraishi Ryoko, Romanowska Malgorzata, Lutzmayer Stefan, Kuiper Jan, Martinez Conception, Dikic Ivan, Pasparakis Manolis, Ikeda Fumiyo

Abstract excerpt

Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation. Mice lacking Sharpin, a critical subunit of LUBAC, spontaneously develop inflammatory lesions in the skin and other organs. Here we show that TNF receptor 1 (TNFR1)-associated death domain (TRADD)-dependent TNFR1 signaling in...

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Share to Epidermis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Keratinocytes

Share to Receptor-Interacting Protein Serine-Threonine Kinases

Share to Receptors, Tumor Necrosis Factor, Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 25443631
DOI: 10.7554/eLife.03422
PMCID: PMC4225491

Genes

FADD
TNF
TRADD
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.PMID 25443631Read ↗

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.Semantic proximity Read ↗

Linear ubiquitination prevents inflammation and regulates immune signalling.Semantic proximity Read ↗

Integrin beta 1 inhibition alleviates the chronic hyperproliferative dermatitis phenotype of SHARPIN-deficient mice.Semantic proximity Read ↗

SHARPIN is a key regulator of immune and inflammatory responses.Semantic proximity Read ↗

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell deathSemantic proximity Read ↗

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.Semantic proximity Read ↗

Human LUBAC deficiency leads to autoinflammation and immunodeficiency by dysregulation in TNF-mediated cell deathSemantic proximity Read ↗

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SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes.Semantic proximity Read ↗

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