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Article

Combined KRAS and TP53 mutation in patients with colorectal cancer enhance chemoresistance to promote postoperative recurrence and metastasis.

BMC cancer - 17 Sept 2024

Tang YiMeng, Fan Yao

Abstract excerpt

The response of patients with colorectal cancer to chemotherapy is tightly correlated with their genomic variation. Among these, APC, TP53, KRAS, PIK3CA are the most frequently mutated genes in advanced colorectal cancer patients. However, the precise correlation between these mutations and the therapeutic effects of chemotherapy remains elusive. Here, we conducted genome sequencing to identify commonly mutated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39289671
DOI: 10.1186/s12885-024-12776-8
PMCID: PMC11409552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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