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The Prognostic Impact of KRAS G12C Mutation in Patients with Metastatic Colorectal Cancer: A Multicenter Retrospective Observational Study.

The oncologist - 1 Oct 2021

Chida Keigo, Kotani Daisuke, Masuishi Toshiki, Kawakami Takeshi, Kawamoto Yasuyuki, Kato Kyoko, Fushiki Kunihiro, Sawada Kentaro, Kumanishi Ryosuke, Shirasu Hiromichi, Matsubara Yuki, Yuki Satoshi, Komatsu Yoshito, Yamazaki Kentaro, Yoshino Takayuki

Abstract excerpt

BACKGROUND: KRAS is one of the most frequently mutated oncogenes in colorectal cancer (CRC). Recently, a novel therapy targeting KRAS G12C mutation has demonstrated promising activities for corresponding advanced solid tumors, including metastatic CRC (mCRC). However, the prognostic impact of the KRAS G12C mutation remains unclear in patients with mCRC. MATERIALS AND METHODS: We retrospectively reviewed medical...

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Identifiers

PMID: 34232546
DOI: 10.1002/onco.13870
PMCID: PMC8488780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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