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Article

KRAS Mutation Status as a Prognostic Marker and Predictor of Therapy Response in Colorectal Cancer: an NCDB Analysis.

Journal of gastrointestinal cancer - 5 Mar 2026

El Sayed Mohyeddine, El Harati Melhem, Shealy Miller W, Youssef Sassine

Abstract excerpt

BACKGROUND: KRAS mutation is a prominent biomarker in colorectal cancer (CRC) and is associated with resistance to anti-EGFR therapy in metastatic disease. However, its prognostic value across stages and its association with survival within common treatment pathways remain incompletely defined in large real-world cohorts. METHODS: We performed a retrospective cohort study using the National Cancer Database,...

Topics

Humans
Colorectal Neoplasms
Proto-Oncogene Proteins p21(ras)
Prognosis
Mutation
Female
Retrospective Studies
Biomarkers, Tumor
Male
Aged
Neoplasm Staging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

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Open in PubMed Open full text

Identifiers

PMID: 41784693
DOI: 10.1007/s12029-026-01439-5
PMCID: PMC12963201

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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