Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Affinity maturation by semi-rational approaches.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Barderas Rodrigo, Desmet Johan, Alard Philippe, Casal J Ignacio

Abstract excerpt

Rational engineering methods can be applied with success to optimize physicochemical characteristics of antibodies. Application of in silico analysis and prediction methods to antibody Fv regions can help to find residues affecting antibody-antigen affinity when high-resolution antibody structures or antibody-antigen complex structures are known. In these cases, the identification of residues affecting affinity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Affinity
Share to Antigen-Antibody Complex
Share to Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrins

Share to Immunoglobulin Variable Region

Share to Molecular Biology

Share to Peptide Library

Share to Single-Chain Antibodies

Source

Identifiers

PMID: 22907369
DOI: 10.1007/978-1-61779-974-7_27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Affinity maturation by semi-rational approaches.PMID 22907369Read ↗

Affinity maturation of antibody fragments: A review encompassing the development from random approaches to computational rational optimization.Semantic proximity Read ↗

Antibody Affinity Maturation by Computational Design.Semantic proximity Read ↗

Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational designSemantic proximity Read ↗

Development and experimental validation of computational methods for human antibody affinity enhancement.Semantic proximity Read ↗

Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation SequencingSemantic proximity Read ↗

Computational design of antibody-affinity improvement beyond in vivo maturation.Semantic proximity Read ↗

Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCRSemantic proximity Read ↗

Protein engineering approaches for antibody fragments: directed evolution and rational design approachesSemantic proximity Read ↗

A Large Language Model Guides the Affinity Maturation of Variant Antibodies Generated by Combinatorial OptimizationSemantic proximity Read ↗

Femtomolar Fab binding affinities to a protein target by alternative CDR residue co-optimization strategies without phage or cell surface display.Semantic proximity Read ↗

Affinity maturation of antibodies assisted by in silico modeling.Semantic proximity Read ↗

Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfacesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.