Article

Vascular normalization in breast cancer confers an endothelial immune suppressive gene expression profile

2026-06-19

Abstract excerpt

Tumors commonly exhibit a leaky vasculature and innate and/or adaptive immune cell infiltration. A recent study showed that a non-leaky and normalized mouse breast cancer vasculature after conditional deletion of the Shb gene in endothelial cells (EC) displayed a suppressive immune cell profile. To extend those findings further, regulation of immunomodulatory gene expression of normalized breast cancer EC was rel...

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Literature Corpus work: 82915ec4-aa2e-59ab-bfc2-d343efffdcc6
DOI: 10.64898/2026.06.17.733057

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