Article
Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1.
Nature communications - 12 Oct 2020
Jiang Huimin, Zhou Chen, Zhang Zhen, Wang Qiong, Wei Huimin, Shi Wen, Li Jianjun, Wang Zhaoyang, Ou Yang, Wang Wenhao, Wang Hang, Zhang Quansheng, Sun Wei, Sun Peiqing, Yang Shuang
Abstract excerpt
Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemness, colonization and the phenotypic plasticity of breast cancer. Moreover, we demonstrate that,...
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