Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches.

doi:10.1371/journal.pcbi.1004050

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Article

Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches.

PLoS computational biology - 1 Mar 2015

Guex Nicolas, Crespo Isaac, Bron Sylvian, Ifticene-Treboux Assia, Faes-Van't Hull Eveline, Kharoubi Solange, Liechti Robin, Werffeli Patricia, Ibberson Mark, Majo Francois, Nicolas Michäel, Laurent Julien, Garg Abhishek, Zaman Khalil, Lehr Hans-Anton, Stevenson Brian J, Rüegg Curzio, Coukos George, Delaloye Jean-François, Xenarios Ioannis, Doucey Marie-Agnès

Abstract excerpt

Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated TEM in human...

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PMID: 25768678
DOI: 10.1371/journal.pcbi.1004050
PMCID: PMC4359163

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