Article
Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.
Breast cancer research and treatment - 1 Aug 2017
Flister Michael J, Tsaih Shirng-Wern, Stoddard Alexander, Plasterer Cody, Jagtap Jaidip, Parchur Abdul K, Sharma Gayatri, Prisco Anthony R, Lemke Angela, Murphy Dana, Al-Gizawiy Mona, Straza Michael, Ran Sophia, Geurts Aron M, Dwinell Melinda R, Greene Andrew S, Bergom Carmen, LaViolette Peter S, Joshi Amit
Abstract excerpt
PURPOSE: Multiple aspects of the tumor microenvironment (TME) impact breast cancer, yet the genetic modifiers of the TME are largely unknown, including those that modify tumor vascular formation and function. METHODS: To discover host TME modifiers, we developed a system called the Consomic/Congenic Xenograft Model (CXM). In CXM, human breast cancer cells are orthotopically implanted into genetically engineered...
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