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Article

Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity.

Cancer research - 15 Aug 2009

Chen Amy, Cuevas Ileana, Kenny Paraic A, Miyake Hiroshi, Mace Kimberley, Ghajar Cyrus, Boudreau Aaron, Bissell Mina J, Bissell Mina, Boudreau Nancy

Abstract excerpt

Recruiting a new blood supply is a rate-limiting step in tumor progression. In a three-dimensional model of breast carcinogenesis, disorganized, proliferative transformed breast epithelial cells express significantly higher expression of angiogenic genes compared with their polarized, growth-arrested nonmalignant counterparts. Elevated vascular endothelial growth factor (VEGF) secretion by malignant cells...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

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Identifiers

PMID: 19654314
DOI: 10.1158/0008-5472.CAN-08-4069
PMCID: PMC2760003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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