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Article

An epigenetic switch in vascular phenotype augments anti-tumor immunity.

Angiogenesis - 19 May 2026

Kim Dae Joong, McGinty Mitchell, Anandh Swetha, Riedstra Caroline, Sethi Yuvraj, Rutkowski Melanie R, Dudley Andrew C

Abstract excerpt

The abnormal tumor vasculature can present a barrier to the infiltration of anti-tumor immune cells, which impairs immune surveillance and response to immunotherapy. Here, we show that genetically deleting the epigenetic factor DNA methyltransferase 1 (Dnmt1) in endothelial cells (ECs) reduces angiogenesis while imparting profound changes to the tumor immune microenvironment (TIME), including increased...

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Share to CD4-Positive T-Lymphocytes
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Epigenesis, Genetic

Share to Melanoma, Experimental

Share to Mice, Knockout

Share to Neovascularization, Pathologic

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 42156591
DOI: 10.1007/s10456-026-10042-y
PMCID: PMC13186828

Genes

CD4
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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