Article

Global Structure of the Intrinsically Disordered Protein Tau Emerges from its Local Structure

2021-11-24

Abstract excerpt

The paradigmatic disordered protein tau plays an important role in neuronal function and neurodegenerative diseases. To disentangle the factors controlling the balance between functional and disease-associated conformational states, we build a structural ensemble of the tau K18 fragment containing the four pseudorepeat domains involved in both microtubule binding and amyloid fibril formation. We assemble 129-resid...

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Literature Corpus work: 828bf5ec-2f1d-526b-a1b7-c3831a5f7340
DOI: 10.1101/2021.11.23.469691

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